◎研究方向
1.微流控
2.功能聚合物-包裹与可控释放
3.非常规采油与多孔介质智能调剖

◎指导研究生
博士生：
2022级：任玲玲，刘爽
欢迎石油工程、化工，高分子、生物，力学等相关专业背景的学生报考博士及硕士研究生

◎承担科研课题
国家自然科学基金面上项目，58万，2021-2026；
国家海外高层次人才引进计划青年项目，250万，2021-2026；
病原体认证，美国国防高级研究计划局，$12,117,522, 2018-2022；
智能驱替材料的合成及应用，大庆油田-金智瑞材料有限公司，$11,000，2019-2020；
基于微流控的用于降低杀虫剂的损失，巴斯夫化学公司，$300,000，2018-2020；
超薄凝胶用于微环境的修复，美国卫生部，$665,836, 2017-2020；
液态金属的包覆以及应用，美国德雷珀实验室，$ 30,000，2019-2020；
智能驱替材料在三次采油的应用，美国石油能源联盟，$1,500,000美元，2011-2016；
以液滴微流控为基础的多层胶囊组装的微流控装置的制备与研究，巴斯夫化学公司， $300,000，2013-2014；

◎荣誉称号
国家特聘青年专家

◎论文
1.Yan Zhang, Xue-Zhi Zhao, Pei-Hui Han, Li-Yuan Zhang, David A Weitz, Yu-Jun Feng, Visualization of adaptive polymer flow and displacement in medium-permeable 3D core-on-a-chip, Petroleum Science, 2022
2.Yi-Ning Wu, Li-Sha Tang, Yuan Li, Li-Yuan Zhang*, Xu Jin, Ming-Wei Zhao, Xiang Feng, Cai-Li Dai, Probing the influence of secondary fracture connectivity on fracturing fluid flowback efficiency, Petroleum Science, 2022
3.Bo Li, Xin Li, Xiaodong Chu, Pengcheng Lou, Yin Yuan, Aoxiang Zhuge, Xueling Zhu, Yangfan Shen, Jinghua Pan, Liyuan Zhang*, Lanjuan Li*, Zhongwen Wu*, Micro-ecology Restoration of Colonic Inflammation by In-Situ Oral Delivery of Antibody-laden Hydrogel Microcapsules, Bioactive Materials, 2022, 15, 305-315
4.Zhijun Li, Yizhou Jiang, Shihuan Tang, Haixia Zou, Wentao Wang, Guangpei Qi, Hongbo Zhang, Kun Jin, Yuhe Wang, Hong Chen, Liyuan Zhang*, Xiangmeng Qu*, 2D nanomaterial sensing array using machine learning for differential profiling of pathogenic microbial taxonomic identification, Microchimica Acta, 2022, 189, 1-14
5.Haoyue Zhang¶¶, Liyuan Zhang¶¶, Chuanfeng An, Yang Zhang, Fei Shao, Yijie Gao, Yonghao Zhang, Hanting Li, Yujie Zhang, Changle Ren, Kai Sun, Wei He, Fang Cheng, Huanan Wang, David A Weitz, Large-scale single-cell encapsulation in microgels through metastable droplet-templating combined with microfluidic-integration, Biofabrication, 2022, 6;14(3)
6.Xiaowan Yuan, Daiqin Xiao, Wei Yao, Zhihao Zhang, Lin Yang, Liyuan Zhang, Yibo Zeng, Jiaqi Liao, Shanxiong Luo, Chonghao Li, Hong Chen, Xiangmeng Qu, High-fidelity transfer of area-selective atomic layer deposition grown HfO2 through DNA origami-assisted nanolithography, Nano Research, 2022, 15, 5687-5694.
7.Zhijun Li, Kun Jin, Hong Chen, Liyuan Zhang*, Guitao Zhang, Yizhou Jiang, Haixia Zou, Wentao Wang, Guangpei Qi, Xiangmeng Qu*, A machine learning approach-based array sensor for rapidly predicting the mechanisms of action of antibacterial compounds, Nanoscale, 2022, 5245-5246.
8.Jienan Shen¶, Liyuan Zhang¶, Junjie Yuan, Yongsheng Zhu, Hao Cheng, Yibo Zeng, Jiaqin Wang, Xueqiu You, Chaoyong Yang, Xiangmeng Qu*, Hong Chen*, Digital Microfluidic Thermal Control Chip-Based Multichannel Immunosensor for Noninvasively Detecting Acute Myocardial Infarction, Analytical Chemistry 2021, 93, 45, 15033-15041
9.Maimaitimin Aizitiaili, Yizhou Jiang, Li Jiang, Xiaowan Yuan, Kun Jin, Hong Chen, Liyuan Zhang*, Xiangmeng Qu*, Programmable Engineering of DNA-AuNP Encoders Integrated Multimodal Coupled Analysis for Precision Discrimination of Multiple Metal Ions, Nano Letter, 2021, 21, 5, 2141-2148
10.Liyuan Zhang, Alireza Abbaspourrad, Shima Parsa, Jizhou Tang, Flavia M Cassiola, Meng Zhang, Shouceng Tian, Caili Dai, Lizhi Xiao, David A Weitz*, Core-shell Nanohydrogels with Programmable Swelling for Conformance Control in Porous Media, ACS Applied Material and Interfaces 2020, 12, 30, 34217–34225
11.Wen Li+¶, Liyuan Zhang+¶, Xuehui Ge+¶, Biyi Xu, Weixia Zhang, Liangliang Qu, Chang-Hyung Choi, Jianhong Xu, Afang Zhang, Hyomin Lee*, David A Weitz*, Microfluidic fabrication of microparticles for biomedical applications, Chemical Society Reviews, 2018, 47, 5646-5683
12.Liyuan Zhang, Chang‐Hyung Choi, Angelo S Mao, Hongbing Liao, Stefanie Utech, David J Mooney, Huanan Wang, David A Weitz, Small, 2018, 14, 1702955
13.Liyuan Zhang, Li‐Heng Cai, Philipp S Lienemann, Torsten Rossow, Ingmar Polenz, Queralt Vallmajo‐Martin, Martin Ehrbar, Hui Na, David J Mooney, David A Weitz, One‐step microfluidic fabrication of polyelectrolyte microcapsules in aqueous conditions for protein release, Angewandte Chemie International Edition, 2016, 128, 13668-13672
14.Anqi Chen, Xue-hui Ge, Jian Chen, Liyuan Zhang*, Jian-Hong Xu*, Multi-functional micromotor: microfluidic fabrication and water treatment application, Lab on a Chip, 2017, 17, 4220-4224
15.Liyuan Zhang, Duo Qi, Chengji Zhao, Hui Na, In-situ self-crosslinked sulfonated poly (arylene ether ketone) with alkyl side chain for enhanced performance, Journal of Membrane Science, 2016, 508, 15-21
16.Liyuan Zhang, Duo Qi, Gang Zhang, Chengji Zhao, Hui Na, Crosslinked tri-side-chain-type sulfonated poly (arylene ether ketones) with enhanced proton conductivity by a Friedel–Crafts acylation reaction, RSC Advances, 2014, 4, 94, 51916-51925
17.Liyuan Zhang, Gang Zhang, Chengji Zhao, Zhongguo Liu, Hao Jiang, Shuai Xu, Mingyu Li, Dan Xu, Hui Na, High proton-conducting polymer electrolytes based on pendent poly (arylene ether ketone) with H-bond for proton exchange membranes, International Journal of Hydrogen Energy, 2013, 38, 12363-12373
18.Liyuan Zhang, Gang Zhang, Chengji Zhao, Hao Jiang, Jing Wang, Dan Xu, Yang Zhang, Ke Shao, Zhongguo Liu, Wengjia Ma, Hongtao Li, Mingyu Li, Shuang Wang, Hui Na, Cross-linked tri-side chains poly (arylene ether ketone) s containing pendant alkylsulfonic acid groups for proton exchange membranes, Journal of Power Sources, 2012, 201, 142-150
19.Chuanfeng An, Weijian Liu, Yang Zhang, Bo Pang, Hui Liu, Yujie Zhang, Haoyue Zhang, Liyuan Zhang, Hongbing Liao, Changle Ren, Huanan Wang, Continuous microfluidic encapsulation of single mesenchymal stem cells using alginate microgels as injectable fillers for bone regeneration, Acta Biomaterialia, Acta Biomaterialia, 2020, 111, 181-196
20.Jizhou Tang, Bo Fan, Lizhi Xiao, Shouceng Tian, Fengshou Zhang, Liyuan Zhang, David Weitz, A New Ensemble Machine-Learning Framework for Searching Sweet Spots in Shale Reservoirs, SPE J. 2020, 26 (01): 482–497
21.Yuwei Li, Yudong Zhao, Jizhou Tang, Liyuan Zhang, Yuyang Zhou, Xiuyu Zhu, Dan Jia, Mian Chen, Rock damage evolution model of pulsating fracturing based on energy evolution theory, Energy Science & Engineering, 2020, 8, 1050-1067
22.Angelo S Mao, Berna Özkale, Nisarg J Shah, Kyle H Vining, Tiphaine Descombes, Liyuan Zhang, Christina M Tringides, Sing-Wan Wong, Jae-Won Shin, David T Scadden, David A Weitz, David J Mooney, Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation, Proceedings of the National Academy of Sciences, 2019, 116, 15392-15397
23.Jie Liu, Xiacong Zhang, Xiao Chen, Liangliang Qu, Liyuan Zhang, Wen Li, Afang Zhang, Stimuli-responsive dendronized polymeric hydrogels through Schiff-base chemistry showing remarkable topological effects, Polymer Chemistry, 2018, 9, 378-387
24.Angelo S Mao, Jae-Won Shin, Stefanie Utech, Huanan Wang, Oktay Uzun, Weiwei Li, Madeline Cooper, Yuebi Hu, Liyuan Zhang, David A Weitz, David J Mooney, Deterministic encapsulation of single cells in thin tunable microgels for niche modelling and therapeutic delivery, Nature Materials, 2017, 16, 236-243
25.Feng Kong, Hongbo Zhang, Xu Zhang, Dongfei Liu, Dong Chen, Weixia Zhang, Liyuan Zhang, Hélder A Santos, Mingtan Hai, Biodegradable photothermal and pH responsive calcium carbonate@ phospholipid@ acetalated dextran hybrid platform for advancing biomedical applications, Advanced Functional Materials, 2016, 26, 6158-6169

◎专利
1.一种微流控装置及利用该装置制备微凝胶的方法
2.一种基于微流控及机器学习的剩余油赋存形态判别方法
3.一种基于微流控与人工智能的油液分析设备故障预测系统
4.一种原油快速定量表征的在线式光谱检测系统及其方法
5.一种基于人工智能的大数据类器官图像识别的方法
6.一种基于微流控技术高通量培养的类器官结构的制备方法
7.基于人工智能和大数据分析的药物筛选模型的搭建方法

◎学术交流
Programmable Nanohydrogel for Flow control in Porous Media, Society of Petrophysicists and Well Log Analysts, Boston, 2018.
Drop-based Microfluidic for Cell Microenvironment Control, ACS-ICHEM meeting, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 2017.
Microfluidic for Controlling Microenvironment, Dalian University of Technology, Dalian, 2017.
Assembly Stem Cell at Single Cell Level by Microfluidic, Shanghai University, Shanghai, 2017.
Mesenchymal Stem Cell 3D Assembly in multi-compartmental micro-hydrogel, Florida A&M University and Florida State University, Tallahassee, 2015.